HPV

KEY POINTS

1. Venereal warts on skin around genitals or internally on female uterine cervix (although HPV disease can be very subtle and difficult to detect)
2. Prevalence: Worldwide
3. HPV is the most common STD in the U.S.
4. HPV is not intended for treatment of active genital warts or cancer.
5. 9 – 26 yrs-old, males and females, to protect against genital warts and cervical, vaginal, and vulvar cancer

Disease: A sexually transmitted viral infection of the genital areas

Presentation: Venereal warts on skin around genitals and internally on female uterine cervix (although HPV disease can be very subtle and difficult to detect)

Complications: Cervical cancer – 3700 U.S. deaths from this each year (233,000 worldwide)

Prevalence:

• Worldwide
• HPV is the most common STD in the U.S.

Transmission: Genital and skin-to-skin contact

Treatment: Cryotherapy of warts

Prevention:

1. Safe sex with barrier methods
2. Vaccine (killed/Gardasil)
   1. 0.5cc, intramuscularly
   2. Primary Series: 3 doses, at time “0”, 1 – 2 mo’s, and 6 mo’s
   3. Side-Effects;
      1. Mild-moderate: Injection site pain, fever, syncope, headache, nausea, joint ache, muscle ache, malaise
      2. Serious (< 0.1%): asthma, diarrhea, hypertension, headache
   4. Precautions/Contraindications
      1. HPV vaccine is not intended for treatment of active genital warts or cancer.
      2. Postpone vaccination when moderately ill.
      3. Systemic allergic reactions to yeast, aluminum, or polysorbate contraindicate the vaccine.
      4. Patients should sit or lie down for 15 min. after vaccination to minimize risk of passing out.
      5. May be given to immune compromised.
      6. Breastfeeding is not a contraindication.
      7. Not recommended with pregnancy (not enough data to establish safety).
   5. Targets
      1. 9 – 26 yrs-old, males and females, to protect against genital warts and cervical, vaginal, and vulvar cancer

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